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Targeting Individual GPCRs with Redesigned Nonvisual Arrestins
Numerous human diseases are caused by excessive signaling of mutant G protein-coupled receptors (GPCRs) or receptors that are overstimulated due to upstream signaling imbalances. The feasibility of functional compensation by arrestins with enhanced ability to quench receptor signaling was recently t...
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| Publicado no: | Handb Exp Pharmacol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4516156/ https://ncbi.nlm.nih.gov/pubmed/24292829 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-3-642-41199-1_8 |
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