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The structural basis of the arrestin binding to GPCRs.
G protein-coupled receptors (GPCRs) are the largest family of signaling proteins targeted by more clinically used drugs than any other protein family. GPCR signaling via G proteins is quenched (desensitized) by the phosphorylation of the active receptor by specific GPCR kinases (GRKs) followed by ti...
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| Publicado no: | Mol Cell Endocrinol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6377262/ https://ncbi.nlm.nih.gov/pubmed/30703488 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2019.01.019 |
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