Manipulation of Very Few Receptor Discriminator Residues Greatly Enhances Receptor Specificity of Non-visual Arrestins

Based on the identification of residues that determine receptor selectivity of arrestins and the analysis of the evolution in the arrestin family, we introduced 10 mutations of “receptor discriminator” residues in arrestin-3. The recruitment of these mutants to M2 muscarinic (M2R), D1 (D1R) and D2 (...

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Bibliographic Details
Main Authors: Gimenez, Luis E., Vishnivetskiy, Sergey A., Baameur, Faiza, Gurevich, Vsevolod V.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436164/
https://ncbi.nlm.nih.gov/pubmed/22787152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.366674
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