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Critical Role of the Central 139-Loop in Stability and Binding Selectivity of Arrestin-1

Arrestin-1 selectively binds active phosphorylated rhodopsin (P-Rh*), demonstrating much lower affinity for inactive phosphorylated (P-Rh) and unphosphorylated active (Rh*) forms. Receptor interaction induces significant conformational changes in arrestin-1, which include large movement of the previ...

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Detalhes bibliográficos
Main Authors: Vishnivetskiy, Sergey A., Baameur, Faiza, Findley, Kristen R., Gurevich, Vsevolod V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636863/
https://ncbi.nlm.nih.gov/pubmed/23476014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.450031
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