Few Residues within an Extensive Binding Interface Drive Receptor Interaction and Determine the Specificity of Arrestin Proteins

Arrestins bind active phosphorylated forms of G protein-coupled receptors, terminating G protein activation, orchestrating receptor trafficking, and redirecting signaling to alternative pathways. Visual arrestin-1 preferentially binds rhodopsin, whereas the two non-visual arrestins interact with hun...

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Detalhes bibliográficos
Main Authors: Vishnivetskiy, Sergey A., Gimenez, Luis E., Francis, Derek J., Hanson, Susan M., Hubbell, Wayne L., Klug, Candice S., Gurevich, Vsevolod V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129209/
https://ncbi.nlm.nih.gov/pubmed/21471193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.213835
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