Few Residues within an Extensive Binding Interface Drive Receptor Interaction and Determine the Specificity of Arrestin Proteins

Arrestins bind active phosphorylated forms of G protein-coupled receptors, terminating G protein activation, orchestrating receptor trafficking, and redirecting signaling to alternative pathways. Visual arrestin-1 preferentially binds rhodopsin, whereas the two non-visual arrestins interact with hun...

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Hlavní autoři: Vishnivetskiy, Sergey A., Gimenez, Luis E., Francis, Derek J., Hanson, Susan M., Hubbell, Wayne L., Klug, Candice S., Gurevich, Vsevolod V.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129209/
https://ncbi.nlm.nih.gov/pubmed/21471193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.213835
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