THE ROLE OF ARRESTIN α-HELIX I IN RECEPTOR BINDING

Arrestins rapidly bind phosphorylated activated forms of their cognate G protein-coupled receptors (GPCRs), thereby preventing G protein coupling and often switching the signaling to other pathways. Amphipathic α-helix I (residues 100–111) has been implicated in receptor binding, but the mechanism o...

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Détails bibliographiques
Auteurs principaux: Vishnivetskiy, Sergey A., Francis, Derek, Van Eps, Ned, Kim, Miyeon, Hanson, Susan M., Klug, Candice S., Hubbell, Wayne L., Gurevich, Vsevolod V.
Format: Artigo
Langue:Inglês
Publié: 2009
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787876/
https://ncbi.nlm.nih.gov/pubmed/19883657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.10.058
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