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THE ROLE OF ARRESTIN α-HELIX I IN RECEPTOR BINDING
Arrestins rapidly bind phosphorylated activated forms of their cognate G protein-coupled receptors (GPCRs), thereby preventing G protein coupling and often switching the signaling to other pathways. Amphipathic α-helix I (residues 100–111) has been implicated in receptor binding, but the mechanism o...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2787876/ https://ncbi.nlm.nih.gov/pubmed/19883657 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.10.058 |
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