Approaches to Assess Biased Signaling at the CB1R Receptor

מאת Laprairie, Robert B., Stahl, Edward L., Bohn, Laura M.
הוצא לאור ב Methods Enzymol (2017)

A Novel Method for Analyzing Extremely Biased Agonism at G Protein–Coupled Receptors

מאת Stahl, Edward L., Zhou, Lei, Ehlert, Frederick J., Bohn, Laura M.
הוצא לאור ב Mol Pharmacol (2015)

G protein signaling–biased agonism at the κ-opioid receptor is maintained in striatal neurons

מאת Ho, Jo-Hao, Stahl, Edward L., Schmid, Cullen L., Scarry, Sarah M., Aubé, Jeffrey, Bohn, Laura M.
הוצא לאור ב Sci Signal (2018)

Characterization of kappa opioid receptor mediated, dynorphin-stimulated [(35)S]GTPγS binding in mouse striatum for the evaluation of selective KOR ligands in an endogenous setting...

מאת Zhou, Lei, Stahl, Edward L., Lovell, Kimberly M., Frankowski, Kevin J., Prisinzano, Thomas E., Aubé, Jeffrey, Bohn, Laura M.
הוצא לאור ב Neuropharmacology (2015)

Structure–Activity Relationship Studies of Functionally Selective Kappa Opioid Receptor Agonists that Modulate ERK 1/2 Phosphorylation While Preserving G Protein Over βArrestin2 Si...

מאת Lovell, Kimberly M., Frankowski, Kevin J., Stahl, Edward L., Slauson, Stephen R., Yoo, Euna, Prisinzano, Thomas E., Aubé, Jeffrey, Bohn, Laura M.
הוצא לאור ב ACS Chem Neurosci (2015)

Arrestin recruitment to dopamine D2 receptor mediates locomotion but not incentive motivation

מאת Donthamsetti, Prashant, Gallo, Eduardo F., Buck, David C., Stahl, Edward L., Zhu, Ying, Lane, J. Robert, Bohn, Laura M., Neve, Kim A., Kellendonk, Christoph, Javitch, Jonathan A.
הוצא לאור ב Mol Psychiatry (2018)

A G protein signaling-biased agonist at the μ-opioid receptor reverses morphine tolerance while preventing morphine withdrawal

מאת Grim, Travis W., Schmid, Cullen L., Stahl, Edward L., Pantouli, Fani, Ho, Jo-Hao, Acevedo-Canabal, Agnes, Kennedy, Nicole M., Cameron, Michael D., Bannister, Thomas D., Bohn, Laura M.
הוצא לאור ב Neuropsychopharmacology (2019)

Probing the CB(1) Cannabinoid Receptor Binding Pocket with AM6538, a High-Affinity Irreversible Antagonist

מאת Laprairie, Robert B., Vemuri, Kiran, Stahl, Edward L., Korde, Anisha, Ho, Jo-Hao, Grim, Travis W., Hua, Tian, Wu, Yiran, Stevens, Raymond C., Liu, Zhi-Jie, Makriyannis, Alexandros, Bohn, Laura M.
הוצא לאור ב Mol Pharmacol (2019)

Characterization of Structurally Novel G Protein Biased CB1 Agonists: Implications for Drug Development

מאת Ford, Benjamin M., Franks, Lirit N., Tai, Sherrica, Fantegrossi, William E., Stahl, Edward L., Berquist, Michael D., Cabanlong, Christian V., Wilson, Catheryn D., Penthala, Narsimha R., Crooks, Peter A., Prather, Paul L.
הוצא לאור ב Pharmacol Res (2017)

Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria

מאת Brust, Tarsis F., Morgenweck, Jenny, Kim, Susy A., Rose, Jamie H., Locke, Jason L., Schmid, Cullen L., Zhou, Lei, Stahl, Edward L., Cameron, Michael D., Scarry, Sarah M., Aubé, Jeffrey, Jones, Sara R., Martin, Thomas J., Bohn, Laura M.
הוצא לאור ב Sci Signal (2016)

Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-G(i) Complex Structures

מאת Hua, Tian, Li, Xiaoting, Wu, Lijie, Iliopoulos-Tsoutsouvas, Christos, Wang, Yuxia, Wu, Meng, Shen, Ling, Brust, Christina A., Nikas, Spyros P., Song, Feng, Song, Xiyong, Yuan, Shuguang, Sun, Qianqian, Wu, Yiran, Jiang, Shan, Grim, Travis W., Benchama, Othman, Stahl, Edward L., Zvonok, Nikolai, Zhao, Suwen, Bohn, Laura M., Makriyannis, Alexandros, Liu, Zhi-Jie
הוצא לאור ב Cell (2020)

Crystal Structure of the Human Cannabinoid Receptor CB(1)

מאת Hua, Tian, Vemuri, Kiran, Pu, Mengchen, Qu, Lu, Han, Gye Won, Wu, Yiran, Zhao, Suwen, Shui, Wenqing, Li, Shanshan, Korde, Anisha, Laprairie, Robert B., Stahl, Edward L., Ho, Jo-Hao, Zvonok, Nikolai, Zhou, Han, Kufareva, Irina, Wu, Beili, Zhao, Qiang, Hanson, Michael A., Bohn, Laura M., Makriyannis, Alexandros, Stevens, Raymond C., Liu, Zhi-Jie
הוצא לאור ב Cell (2016)