Functional Studies Cast Light on Receptor States

le Ehlert, Frederick J.
Foilsithe in Trends Pharmacol Sci (2015)

Investigating the Interaction of McN-A-343 with the M(2) Muscarinic Receptor Using its Nitrogen Mustard Derivative

le Suga, Hinako, Ehlert, Frederick J.
Foilsithe 2009

Effects of asparagine mutagenesis of conserved aspartic acids in helix two (D2.50) and three (D3.32) of M(1) – M(4) muscarinic receptors on the irreversible binding of nitrogen mus...

le Suga, Hinako, Ehlert, Frederick J.
Foilsithe 2013

Estimation of Ligand Affinity Constants for Receptor States in Functional Studies Involving the Allosteric Modulation of G Protein-Coupled Receptors: Implications for Ligand Bias

le Ehlert, Frederick J., Griffin, Michael T.
Foilsithe 2014

Analysis of Functional Responses at G Protein-Coupled Receptors: Estimation of Relative Affinity Constants for the Inactive Receptor State

le Ehlert, Frederick J., Griffin, Michael T., Suga, Hinako
Foilsithe 2011

Analysis of Agonism and Inverse Agonism in Functional Assays with Constitutive Activity: Estimation of Orthosteric Ligand Affinity Constants for Active and Inactive Receptor States

le Ehlert, Frederick J., Suga, Hinako, Griffin, Michael T.
Foilsithe 2011

Quantifying Agonist Activity at G Protein-coupled Receptors

le Ehlert, Frederick J., Suga, Hinako, Griffin, Michael T.
Foilsithe 2011

Estimation of the receptor-state affinity constants of ligands in functional studies using wild type and constitutively active mutant receptors: Implications for estimation of agon...

le Ehlert, Frederick J., Stein, Richard S.L.
Foilsithe in J Pharmacol Toxicol Methods (2016)

Functional role of muscarinic M(2) receptors in α,β-methylene ATP induced, neurogenic contractions in guinea-pig ileum

le Sawyer, Gregory W, Lambrecht, Günter, Ehlert, Frederick J
Foilsithe 2000

Selectivity of Agonists for the Active State of M(1) to M(4) Muscarinic Receptor Subtypes

le Figueroa, Katherine W., Griffin, Michael T., Ehlert, Frederick J.
Foilsithe 2009

Use of acetylcholine mustard to study allosteric interactions at the M(2) muscarinic receptor

le Suga, Hinako, Figueroa, Katherine W., Ehlert, Frederick J.
Foilsithe 2008

Mutagenesis of Nucleophilic Residues near the Orthosteric Binding Pocket of M(1) and M(2) Muscarinic receptors: Effect on the Binding of Nitrogen Mustard Analogs of Acetylcholine a...

le Suga, Hinako, Sawyer, Gregory W., Ehlert, Frederick J.
Foilsithe 2010

The guinea pig ileum lacks the direct, high-potency, M(2)-muscarinic, contractile mechanism characteristic of the mouse ileum

le Griffin, Michael T., Matsui, Minoru, Ostrom, Rennolds S., Ehlert, Frederick J.
Foilsithe 2009

A Conserved Motif in the Membrane Proximal C-Terminal Tail of Human Muscarinic M(1) Acetylcholine Receptors Affects Plasma Membrane Expression

le Sawyer, Gregory W., Ehlert, Frederick J., Shults, Crystal A.
Foilsithe 2010

Estimation of Relative Microscopic Affinity Constants of Agonists for the Active State of the Receptor in Functional Studies on M(2) and M(3) Muscarinic Receptors

le Tran, John A., Chang, Alexander, Matsui, Minoru, Ehlert, Frederick J.
Foilsithe 2009

A Novel Method for Analyzing Extremely Biased Agonism at G Protein–Coupled Receptors

le Stahl, Edward L., Zhou, Lei, Ehlert, Frederick J., Bohn, Laura M.
Foilsithe in Mol Pharmacol (2015)

Intrinsic Relative Activities of Opioid Agonists in Activating Gα proteins and Internalizing Receptor: Differences between Human and Mouse Receptors

le DiMattio, Kelly M., Ehlert, Frederick J., Liu-Chen, Lee-Yuan
Foilsithe in Eur J Pharmacol (2015)

PDE8 Is Expressed in Human Airway Smooth Muscle and Selectively Regulates cAMP Signaling by β(2)-Adrenergic Receptors and Adenylyl Cyclase 6

le Johnstone, Timothy B., Smith, Kaitlyn H., Koziol-White, Cynthia J., Li, Fengying, Kazarian, Austin G., Corpuz, Maia L., Shumyatcher, Maya, Ehlert, Frederick J., Himes, Blanca E., Panettieri, Reynold A., Ostrom, Rennolds S.
Foilsithe in Am J Respir Cell Mol Biol (2018)