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A Conserved Motif in the Membrane Proximal C-Terminal Tail of Human Muscarinic M(1) Acetylcholine Receptors Affects Plasma Membrane Expression
We investigated the functional role of a conserved motif, F(x)(6)LL, in the membrane proximal C-tail of the human muscarinic M(1) (hM(1)) receptor. By use of site-directed mutagenesis, several different point mutations were introduced into the C-tail sequence (423)FRDTFRLLL(431). Wild-type and mutan...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2802481/ https://ncbi.nlm.nih.gov/pubmed/19841475 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.160986 |
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