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Selectivity of Agonists for the Active State of M(1) to M(4) Muscarinic Receptor Subtypes
We measured the intrinsic relative activity (RA(i)) of muscarinic agonists to detect possible selectivity for receptor subtypes and signaling pathways. RA(i) is a relative measure of the microscopic affinity constant of an agonist for the active state of a GPCR expressed relative to that of a standa...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Pharmacology and Experimental Therapeutics
2009
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2644050/ https://ncbi.nlm.nih.gov/pubmed/18824613 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.108.145219 |
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