Selectivity of Agonists for the Active State of M(1) to M(4) Muscarinic Receptor Subtypes

We measured the intrinsic relative activity (RA(i)) of muscarinic agonists to detect possible selectivity for receptor subtypes and signaling pathways. RA(i) is a relative measure of the microscopic affinity constant of an agonist for the active state of a GPCR expressed relative to that of a standa...

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Bibliographic Details
Main Authors: Figueroa, Katherine W., Griffin, Michael T., Ehlert, Frederick J.
Format: Artigo
Language:Inglês
Published: American Society for Pharmacology and Experimental Therapeutics 2009
Subjects:
Cellular and Molecular
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2644050/
https://ncbi.nlm.nih.gov/pubmed/18824613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.108.145219
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