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Discovery of Selective M4 Muscarinic Acetylcholine Receptor Agonists with Novel Carbamate Isosteres

[Image: see text] It has been hypothesized that selective muscarinic acetylcholine receptor (mAChR) M4 subtype activation could provide therapeutic benefits to a number of neurological disorders while minimizing unwanted cholinergic side effects observed due to nonselective mAChR activation. Given t...

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書目詳細資料
發表在:ACS Med Chem Lett
Main Authors: Yang, Qingyi, Lachapelle, Erik A., Kablaoui, Natasha M., Webb, Damien, Popiolek, Michael, Grimwood, Sarah, Kozak, Rouba, O’Connor, Rebecca E., Lazzaro, John T., Butler, Christopher R., Zhang, Lei
格式: Artigo
語言:Inglês
出版: American Chemical Society 2019
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6580797/
https://ncbi.nlm.nih.gov/pubmed/31223452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00106
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