Muscarinic agonist, (±)-quinuclidin-3-yl-(4-fluorophenethyl)(phenyl) carbamate: High affinity, but low subtype selectivity for human M(1) – M(5) muscarinic acetylcholine receptors

Novel quinuclidinyl N-phenylcarbamate analogs were synthesized, and binding affinities at M(1)-M(5) muscarinic acetylcholine receptor (mAChR) subtypes were determined using Chinese hamster ovary (CHO) cell membranes stably expressing one specific subtype of human mAChR. Although not subtype selectiv...

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Veröffentlicht in:Bioorg Med Chem Lett
Hauptverfasser: Lee, Na-Ra, Gujarathi, Satheesh, Bommagani, Shobanbabu, Siripurapu, Kiranbabu, Zheng, Guangrong, Dwoskin, Linda P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7160324/
https://ncbi.nlm.nih.gov/pubmed/30554957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.12.022
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