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Muscarinic agonist, (±)-quinuclidin-3-yl-(4-fluorophenethyl)(phenyl) carbamate: High affinity, but low subtype selectivity for human M(1) – M(5) muscarinic acetylcholine receptors
Novel quinuclidinyl N-phenylcarbamate analogs were synthesized, and binding affinities at M(1)-M(5) muscarinic acetylcholine receptor (mAChR) subtypes were determined using Chinese hamster ovary (CHO) cell membranes stably expressing one specific subtype of human mAChR. Although not subtype selectiv...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7160324/ https://ncbi.nlm.nih.gov/pubmed/30554957 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.12.022 |
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