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Muscarinic acetylcholine receptor binding affinities of pethidine analogs
A series of pethidine analogs were synthesized and their affinities for the [(3)H]N-methylscopolamine (NMS) binding site on muscarinic acetylcholine receptors (mAChRs) were determined using M(1), M(3) or M(5) human mAChRs expressed by Chinese hamsters ovary (CHO) cell membranes. Compound 6b showed t...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4629469/ https://ncbi.nlm.nih.gov/pubmed/26494260 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.10.029 |
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