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Muscarinic acetylcholine receptor binding affinities of pethidine analogs

A series of pethidine analogs were synthesized and their affinities for the [(3)H]N-methylscopolamine (NMS) binding site on muscarinic acetylcholine receptors (mAChRs) were determined using M(1), M(3) or M(5) human mAChRs expressed by Chinese hamsters ovary (CHO) cell membranes. Compound 6b showed t...

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Bibliografski detalji
Izdano u:Bioorg Med Chem Lett
Glavni autori: Lee, Na-Ra, Zhang, Xuan, Darna, Mahesh, Dwoskin, Linda P., Zheng, Guangrong
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4629469/
https://ncbi.nlm.nih.gov/pubmed/26494260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.10.029
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