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Selectivity of Agonists for the Active State of M(1) to M(4) Muscarinic Receptor Subtypes

We measured the intrinsic relative activity (RA(i)) of muscarinic agonists to detect possible selectivity for receptor subtypes and signaling pathways. RA(i) is a relative measure of the microscopic affinity constant of an agonist for the active state of a GPCR expressed relative to that of a standa...

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Autors principals: Figueroa, Katherine W., Griffin, Michael T., Ehlert, Frederick J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Pharmacology and Experimental Therapeutics 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2644050/
https://ncbi.nlm.nih.gov/pubmed/18824613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.108.145219
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