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Mutagenesis of Nucleophilic Residues near the Orthosteric Binding Pocket of M(1) and M(2) Muscarinic receptors: Effect on the Binding of Nitrogen Mustard Analogs of Acetylcholine and McN-A-343
Investigating how a test drug alters the reaction of a site-directed electrophile with a receptor is a powerful method for determining whether the drug acts competitively or allosterically, provided that the binding site of the electrophile is known. In this study, therefore, we mutated nucleophilic...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The American Society for Pharmacology and Experimental Therapeutics
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2981396/ https://ncbi.nlm.nih.gov/pubmed/20643905 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.065367 |
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