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Effects of asparagine mutagenesis of conserved aspartic acids in helix two (D2.50) and three (D3.32) of M(1) – M(4) muscarinic receptors on the irreversible binding of nitrogen mustard analogs of acetylcholine and McN-A-343

We investigated how asparagine mutagenesis of conserved aspartic acids in helix two (D2.50) and three (D3.32) of M(1) – M(4) muscarinic receptors alters the irreversible binding of acetylcholine mustard and BR384 (4-[(2-bromoethyl)methyl-amino]-2-butynyl N-(3-chlorophenyl)carbamate), a nitrogen must...

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Detalhes bibliográficos
Main Authors: Suga, Hinako, Ehlert, Frederick J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3855626/
https://ncbi.nlm.nih.gov/pubmed/23826889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi4003698
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