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Investigating the interaction of McN-A-343 with the M(1) muscarinic receptor using its nitrogen mustard derivative and ACh mustard
BACKGROUND AND PURPOSE: We investigated how McN-A-343 inhibited the alkylation of the M(1) muscarinic receptor by its nitrogen mustard derivative and that of ACh to identify whether it interacts allosterically or orthosterically. EXPERIMENTAL APPROACH: We incubated the M(1) muscarinic receptor expre...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Publishing Ltd
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2938823/ https://ncbi.nlm.nih.gov/pubmed/20590642 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00810.x |
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