PDE8 Is Expressed in Human Airway Smooth Muscle and Selectively Regulates cAMP Signaling by β(2)-Adrenergic Receptors and Adenylyl Cyclase 6

Two cAMP signaling compartments centered on adenylyl cyclase (AC) exist in human airway smooth muscle (HASM) cells, one containing β(2)-adrenergic receptor AC6 and another containing E prostanoid receptor AC2. We hypothesized that different PDE isozymes selectively regulate cAMP signaling in each co...

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Dettagli Bibliografici
Pubblicato in:Am J Respir Cell Mol Biol
Autori principali: Johnstone, Timothy B., Smith, Kaitlyn H., Koziol-White, Cynthia J., Li, Fengying, Kazarian, Austin G., Corpuz, Maia L., Shumyatcher, Maya, Ehlert, Frederick J., Himes, Blanca E., Panettieri, Reynold A., Ostrom, Rennolds S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Thoracic Society 2018
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5894499/
https://ncbi.nlm.nih.gov/pubmed/29262264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2017-0294OC
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