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Effect of Adenylyl Cyclase Type 6 on Localized Production of cAMP by β-2 Adrenoceptors in Human Airway Smooth-Muscle Cells

β(2)-Adrenoceptors (β(2)ARs) are concentrated in caveolar lipid raft domains of the plasma membrane in airway smooth-muscle (ASM) cells, along with adenylyl cyclase type 6 (AC6). This is believed to contribute to how these receptors can selectively regulate certain types of cAMP-dependent responses...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Agarwal, Shailesh R., Fiore, Chase, Miyashiro, Kathryn, Ostrom, Rennolds S., Harvey, Robert D.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548981/
https://ncbi.nlm.nih.gov/pubmed/31068382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.119.256594
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