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Non-raft adenylyl cyclase 2 defines a cAMP signaling compartment that selectively regulates IL-6 expression in airway smooth muscle cells: differential regulation of gene expression by AC isoforms

Adenylyl cyclase (AC) isoforms differ in their tissue distribution, cellular localization, regulation, and protein interactions. Most cell types express multiple AC isoforms. We hypothesized that cAMP produced by different AC isoforms regulates unique cellular responses in human bronchial smooth mus...

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Publicado en:Naunyn Schmiedebergs Arch Pharmacol
Autores principales: Bogard, Amy S., Birg, Anna V., Ostrom, Rennolds S
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8297510/
https://ncbi.nlm.nih.gov/pubmed/24363043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00210-013-0950-4
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