Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria

Agonists targeting the kappa opioid receptor (KOR) have been promising therapeutic candidates because of their efficacy for treating intractable itch and relieving pain. Unlike typical opioid narcotics, KOR agonists do not produce euphoria or lead to respiratory suppression or overdose. However, the...

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Publicat a:Sci Signal
Autors principals: Brust, Tarsis F., Morgenweck, Jenny, Kim, Susy A., Rose, Jamie H., Locke, Jason L., Schmid, Cullen L., Zhou, Lei, Stahl, Edward L., Cameron, Michael D., Scarry, Sarah M., Aubé, Jeffrey, Jones, Sara R., Martin, Thomas J., Bohn, Laura M.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5231411/
https://ncbi.nlm.nih.gov/pubmed/27899527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aai8441
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