Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria

Agonists targeting the kappa opioid receptor (KOR) have been promising therapeutic candidates because of their efficacy for treating intractable itch and relieving pain. Unlike typical opioid narcotics, KOR agonists do not produce euphoria or lead to respiratory suppression or overdose. However, the...

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Veröffentlicht in:Sci Signal
Hauptverfasser: Brust, Tarsis F., Morgenweck, Jenny, Kim, Susy A., Rose, Jamie H., Locke, Jason L., Schmid, Cullen L., Zhou, Lei, Stahl, Edward L., Cameron, Michael D., Scarry, Sarah M., Aubé, Jeffrey, Jones, Sara R., Martin, Thomas J., Bohn, Laura M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5231411/
https://ncbi.nlm.nih.gov/pubmed/27899527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aai8441
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