Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria

Agonists targeting the kappa opioid receptor (KOR) have been promising therapeutic candidates because of their efficacy for treating intractable itch and relieving pain. Unlike typical opioid narcotics, KOR agonists do not produce euphoria or lead to respiratory suppression or overdose. However, the...

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Bibliographic Details
Published in:Sci Signal
Main Authors: Brust, Tarsis F., Morgenweck, Jenny, Kim, Susy A., Rose, Jamie H., Locke, Jason L., Schmid, Cullen L., Zhou, Lei, Stahl, Edward L., Cameron, Michael D., Scarry, Sarah M., Aubé, Jeffrey, Jones, Sara R., Martin, Thomas J., Bohn, Laura M.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5231411/
https://ncbi.nlm.nih.gov/pubmed/27899527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aai8441
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