A G protein signaling-biased agonist at the μ-opioid receptor reverses morphine tolerance while preventing morphine withdrawal

It has been demonstrated that opioid agonists that preferentially act at μ-opioid receptors to activate G protein signaling over βarrestin2 recruitment produce antinociception with less respiratory suppression. However, most of the adverse effects associated with opioid therapeutics are realized aft...

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Udgivet i:Neuropsychopharmacology
Main Authors: Grim, Travis W., Schmid, Cullen L., Stahl, Edward L., Pantouli, Fani, Ho, Jo-Hao, Acevedo-Canabal, Agnes, Kennedy, Nicole M., Cameron, Michael D., Bannister, Thomas D., Bohn, Laura M.
Format: Artigo
Sprog:Inglês
Udgivet: Springer International Publishing 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901606/
https://ncbi.nlm.nih.gov/pubmed/31443104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-019-0491-8
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