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Synthesis and Evaluation of Novel Biased μ-Opioid-Receptor (μOR) Agonists
‘Biased’ ligands of G protein-coupled receptors (GPCRs) represent a type of promising analgesic with reduced on-target side effects. PZM21, a potent μ-opioid-receptor (μOR)-biased agonist with a new chemical scaffold compared to classic opioids, has been identified as a therapeutic lead molecule for...
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| Publicat a: | Molecules |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
MDPI
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6359544/ https://ncbi.nlm.nih.gov/pubmed/30641969 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24020259 |
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