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Discovery of μ,δ-Opioid Receptor Dual-Biased Agonists That Overcome the Limitation of Prior Biased Agonists
[Image: see text] Morphine is widely used in pain management although the risk of side effects is significant. The use of biased agonists to the G protein of μ-opioid receptors has been suggested as a potential solution, although oliceridine and PZM21 have previously failed to demonstrate benefits i...
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| Udgivet i: | ACS Pharmacol Transl Sci |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American
Chemical Society
2021
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| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8204323/ https://ncbi.nlm.nih.gov/pubmed/34151205 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.1c00044 |
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