Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity

G protein-coupled receptors play a pivotal role in many physiological signaling pathways. Mounting evidence suggests that G protein-coupled receptors, including opioid receptors, form dimers, and dimerization is necessary for receptor maturation, signaling, and trafficking. However, the physiologica...

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Autori principali: Gomes, Ivone, Fujita, Wakako, Gupta, Achla, Saldanha, S. Adrian, Negri, Ana, Pinello, Christine E., Eberhart, Christina, Roberts, Edward, Filizola, Marta, Hodder, Peter, Devi, Lakshmi A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2013
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3718106/
https://ncbi.nlm.nih.gov/pubmed/23818586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1222044110
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