Synthesis and Pharmacology of a Novel μ–δ Opioid Receptor Heteromer-Selective Agonist Based on the Carfentanyl Template

In this work, we studied a series of carfentanyl amide-based opioid derivatives targeting the mu opioid receptor (μOR) and the delta opioid receptor (δOR) heteromer as a credible novel target in pain management therapy. We identified a lead compound named MP135 that exhibits high G-protein activity...

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書誌詳細
出版年:J Med Chem
主要な著者: Faouzi, Abdelfattah, Uprety, Rajendra, Gomes, Ivone, Massaly, Nicolas, Keresztes, Attila I., Le Rouzic, Valerie, Gupta, Achla, Zhang, Tiffany, Yoon, Hye Jean, Ansonoff, Michael, Allaoa, Abdullah, Pan, Ying Xian, Pintar, John, Morón, Jose A., Streicher, John M., Devi, Lakshmi A., Majumdar, Susruta
フォーマット: Artigo
言語:Inglês
出版事項: 2020
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7745089/
https://ncbi.nlm.nih.gov/pubmed/33170687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00901
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