Synthesis and Pharmacology of a Novel μ–δ Opioid Receptor Heteromer-Selective Agonist Based on the Carfentanyl Template

In this work, we studied a series of carfentanyl amide-based opioid derivatives targeting the mu opioid receptor (μOR) and the delta opioid receptor (δOR) heteromer as a credible novel target in pain management therapy. We identified a lead compound named MP135 that exhibits high G-protein activity...

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Publicado en:J Med Chem
Autores principales: Faouzi, Abdelfattah, Uprety, Rajendra, Gomes, Ivone, Massaly, Nicolas, Keresztes, Attila I., Le Rouzic, Valerie, Gupta, Achla, Zhang, Tiffany, Yoon, Hye Jean, Ansonoff, Michael, Allaoa, Abdullah, Pan, Ying Xian, Pintar, John, Morón, Jose A., Streicher, John M., Devi, Lakshmi A., Majumdar, Susruta
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7745089/
https://ncbi.nlm.nih.gov/pubmed/33170687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00901
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