Pharmacologic Characterization in the Rat of a Potent Analgesic Lacking Respiratory Depression, IBNtxA

IBNtxA (3′-iodobenzoyl-6β-naltrexamide) is a potent analgesic in mice lacking many traditional opioid side effects. In mice, it displays no respiratory depression, does not produce physical dependence with chronic administration, and shows no cross-tolerance to morphine. It has limited effects on ga...

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Bibliografiske detaljer
Main Authors: Grinnell, Steven G., Majumdar, Susruta, Narayan, Ankita, Le Rouzic, Valerie, Ansonoff, Michael, Pintar, John E., Pasternak, Gavril W.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2014
Fag:
Neuropharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4152881/
https://ncbi.nlm.nih.gov/pubmed/24970924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.213199
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