Broad spectrum analgesic efficacy of IBNtxA is mediated by exon 11-associated splice variants of the mu-opioid receptor gene

Mu-opioids remain vastly important for the treatment of pain, and would represent ideal analgesics if their analgesic effects could be separated from their many side effects. A recently synthesized compound, iodobenzoylnaltrexamide (IBNtxA), acting at 6-transmembrane (6-TM) splice variants of the mu...

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Publicado no:Pain
Main Authors: Wieskopf, Jeffrey S., Pan, Ying-Xian, Marcovitz, Jaclyn, Tuttle, Alexander H., Majumdar, Susruta, Pidakala, John, Pasternak, Gavril W., Mogil, Jeffrey S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4372857/
https://ncbi.nlm.nih.gov/pubmed/25093831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pain.2014.07.014
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