Abuse Liability, Anti-Nociceptive, and Discriminative Stimulus Properties of IBNtxA

[Image: see text] IBNtxA (3-iodobenzoyl naltrexamine) is a novel μ-opioid receptor (MOR) agonist which is structurally related to the MOR antagonist naltrexone. Recent studies suggest IBNtxA preferentially signals through truncated MOR splice variants, resulting in anti-nociception with reduced side...

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Udgivet i:ACS Pharmacol Transl Sci
Main Authors: Islam, Ariful, Rahman, Mohammad Atiqur, Brenner, Megan B., Moore, Allamar, Kellmyer, Alyssa, Buechler, Harley M., DiGiorgio, Frank, Verchio, Vincent R., McCracken, Laura, Sumi, Mousumi, Hartley, Robert, Lizza, Joseph R., Moura-Letts, Gustavo, Fischer, Bradford D., Keck, Thomas M.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2020
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7551712/
https://ncbi.nlm.nih.gov/pubmed/33073190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.0c00066
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