Synthesis and evaluation of aryl-naloxamide opiate analgesics targeting truncated exon 11-associated mu opioid receptor (MOR-1) splice variants

3-Iodobenzoylnaltrexamide 1 (IBNtxA) is a potent analgesic acting through a novel receptor target that lack many side-effects of traditional opiates composed, in part, of exon 11-associated truncated six transmembrane domain MOR-1 (6TM/E11) splice variants. To better understand the SAR of this drug...

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Detalhes bibliográficos
Main Authors: Majumdar, Susruta, Subrath, Joan, Le Rouzic, Valerie, Polikar, Lisa, Burgman, Maxim, Nagakura, Kuni, Ocampo, Julie, Haselton, Nathan, Pasternak, Anna R., Grinnell, Steven, Pan, Ying-Xian, Pasternak, Gavril W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412067/
https://ncbi.nlm.nih.gov/pubmed/22734622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300305c
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