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Truncated mu opioid receptors with six transmembrane domains are essential for opioid analgesia

BACKGROUND: Most clinical opioids act through mu opioid receptors. They effectively relieve pain, but are limited by side-effects, such as constipation, respiratory depression, dependence and addiction. Many efforts have been made towards developing potent analgesics lacking side effects. 3-iodobenz...

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Podrobná bibliografie
Vydáno v:Anesth Analg
Hlavní autoři: Lu, Zhigang, Xu, Jin., Xu, Mingming, Rossi, Grace C., Majumdar, Susruta, Pasternak, Gavril W., Pan, Ying-Xian
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5820199/
https://ncbi.nlm.nih.gov/pubmed/28991118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1213/ANE.0000000000002538
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