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Tetrapeptide endomorphin analogs require both full length and truncated splice variants of the mu opioid receptor gene Oprm1 for analgesia
The mu opioid receptor gene undergoes extensive alternative splicing. Mu opioids can be divided into three classes based on the role of different groups of splice variants. Morphine and methadone require only full length 7 transmembrane (7TM) variants for analgesia, whereas IBNtxA (3’-iodobenzyol-6β...
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| I publikationen: | ACS Chem Neurosci |
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| Huvudupphovsmän: | , , , , , , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2016
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5177531/ https://ncbi.nlm.nih.gov/pubmed/27648914 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.6b00240 |
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