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Mu opioids induce biased signaling at the full-length seven transmembrane C-terminal splice variants of the mu opioid receptor gene, Oprm1

The biased signaling has been extensively studied in the original mu opioid receptor (MOR-1), particularly through G protein and β-arrestin2 signaling pathways. The concept that the G protein pathway is often linked to the therapeutic effect of the drug, while the β-arrestin pathway is associated to...

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書目詳細資料
發表在:Cell Mol Neurobiol
Main Authors: Narayan, Ankita, Hunkele, Amanda, Xu, Jin, Bassoni, Daniel L., Pasternak, Gavril W., Pan, Ying-Xian
格式: Artigo
語言:Inglês
出版: 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8026774/
https://ncbi.nlm.nih.gov/pubmed/33033993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10571-020-00973-5
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