Truncated mu opioid GPCR variant involvement in opioid-dependent and opioid-independent pain modulatory systems within the CNS

The clinical management of severe pain depends heavily on opioids acting through mu opioid receptors encoded by the Oprm1 gene, which undergoes extensive alternative splicing. In addition to generating a series of prototypic seven transmembrane domain (7TM) G protein-coupled receptors (GPCRs), Oprm1...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Marrone, Gina F., Grinnell, Steven G., Lu, Zhigang, Rossi, Grace C., Le Rouzic, Valerie, Xu, Jin, Majumdar, Susruta, Pan, Ying-Xian, Pasternak, Gavril W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822618/
https://ncbi.nlm.nih.gov/pubmed/26976581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1523894113
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