Truncated mu opioid GPCR variant involvement in opioid-dependent and opioid-independent pain modulatory systems within the CNS

The clinical management of severe pain depends heavily on opioids acting through mu opioid receptors encoded by the Oprm1 gene, which undergoes extensive alternative splicing. In addition to generating a series of prototypic seven transmembrane domain (7TM) G protein-coupled receptors (GPCRs), Oprm1...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Marrone, Gina F., Grinnell, Steven G., Lu, Zhigang, Rossi, Grace C., Le Rouzic, Valerie, Xu, Jin, Majumdar, Susruta, Pan, Ying-Xian, Pasternak, Gavril W.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2016
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822618/
https://ncbi.nlm.nih.gov/pubmed/26976581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1523894113
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