Truncated mu opioid GPCR variant involvement in opioid-dependent and opioid-independent pain modulatory systems within the CNS

The clinical management of severe pain depends heavily on opioids acting through mu opioid receptors encoded by the Oprm1 gene, which undergoes extensive alternative splicing. In addition to generating a series of prototypic seven transmembrane domain (7TM) G protein-coupled receptors (GPCRs), Oprm1...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Marrone, Gina F., Grinnell, Steven G., Lu, Zhigang, Rossi, Grace C., Le Rouzic, Valerie, Xu, Jin, Majumdar, Susruta, Pan, Ying-Xian, Pasternak, Gavril W.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2016
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822618/
https://ncbi.nlm.nih.gov/pubmed/26976581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1523894113
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