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Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects

Pain remains a pervasive problem throughout medicine, transcending all specialty boundaries. Despite the extraordinary insights into pain and its mechanisms over the past few decades, few advances have been made with analgesics. Most pain remains treated by opiates, which have significant side effec...

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Detalhes bibliográficos
Main Authors: Majumdar, Susruta, Grinnell, Steven, Le Rouzic, Valerie, Burgman, Maxim, Polikar, Lisa, Ansonoff, Michael, Pintar, John, Pan, Ying-Xian, Pasternak, Gavril W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3241767/
https://ncbi.nlm.nih.gov/pubmed/22106286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1115231108
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