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Mediation of opioid analgesia by a truncated 6-transmembrane GPCR
The generation of potent opioid analgesics that lack the side effects of traditional opioids may be possible by targeting truncated splice variants of the μ-opioid receptor. μ-Opioids act through GPCRs that are generated from the Oprm1 gene, which undergoes extensive alternative splicing. The most a...
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| Publicado no: | J Clin Invest |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4563690/ https://ncbi.nlm.nih.gov/pubmed/26011641 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI81070 |
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