Synthesis and Pharmacology of a Novel μ–δ Opioid Receptor Heteromer-Selective Agonist Based on the Carfentanyl Template

In this work, we studied a series of carfentanyl amide-based opioid derivatives targeting the mu opioid receptor (μOR) and the delta opioid receptor (δOR) heteromer as a credible novel target in pain management therapy. We identified a lead compound named MP135 that exhibits high G-protein activity...

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Detaylı Bibliyografya
Yayımlandı:J Med Chem
Asıl Yazarlar: Faouzi, Abdelfattah, Uprety, Rajendra, Gomes, Ivone, Massaly, Nicolas, Keresztes, Attila I., Le Rouzic, Valerie, Gupta, Achla, Zhang, Tiffany, Yoon, Hye Jean, Ansonoff, Michael, Allaoa, Abdullah, Pan, Ying Xian, Pintar, John, Morón, Jose A., Streicher, John M., Devi, Lakshmi A., Majumdar, Susruta
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7745089/
https://ncbi.nlm.nih.gov/pubmed/33170687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00901
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