Agonists at the δ-opioid receptor modify the binding of µ-receptor agonists to the µ–δ receptor hetero-oligomer

BACKGROUND AND PURPOSE: µ- and δ-opioid receptors form heteromeric complexes with unique ligand binding and G protein-coupling profiles linked to G protein α z-subunit (Gα(z)) activation. However, the mechanism of action of agonists and their regulation of the µ–δ receptor heteromer are not well und...

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Autores principales: Kabli, N, Martin, N, Fan, T, Nguyen, T, Hasbi, A, Balboni, G, O'Dowd, BF, George, SR
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 2010
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998692/
https://ncbi.nlm.nih.gov/pubmed/20977461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00944.x
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