Optimization of a Series of Mu Opioid Receptor (MOR) Agonists with High G Protein Signaling Bias

While mu opioid receptor (MOR) agonists are especially effective as broad-spectrum pain relievers, it has been exceptionally difficult to achieve a clear separation of analgesia from many problematic side effects. Recently, many groups have sought MOR agonists that induce minimal βarrestin-mediated...

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Detalhes bibliográficos
Publicado no:J Med Chem
Principais autores: Kennedy, Nicole M., Schmid, Cullen L., Ross, Nicolette C., Lovell, Kimberly M., Yue, Zhizhou, Chen, Yen Ting, Cameron, Michael D., Bohn, Laura M., Bannister, Thomas D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6386185/
https://ncbi.nlm.nih.gov/pubmed/30199635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01136
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