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Molecular Mechanisms of Bitopic Ligand Engagement with the M(1) Muscarinic Acetylcholine Receptor
TBPB and 77-LH-28-1 are selective agonists of the M(1) muscarinic acetylcholine receptor (mAChR) that may gain their selectivity through a bitopic mechanism, interacting concomitantly with the orthosteric site and part of an allosteric site. The current study combined site-directed mutagenesis, anal...
Gorde:
| Egile Nagusiak: | , , , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
American Society for Biochemistry and Molecular Biology
2014
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4156061/ https://ncbi.nlm.nih.gov/pubmed/25006252 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.582874 |
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