Molecular Mechanisms of Bitopic Ligand Engagement with the M(1) Muscarinic Acetylcholine Receptor

TBPB and 77-LH-28-1 are selective agonists of the M(1) muscarinic acetylcholine receptor (mAChR) that may gain their selectivity through a bitopic mechanism, interacting concomitantly with the orthosteric site and part of an allosteric site. The current study combined site-directed mutagenesis, anal...

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Hlavní autoři: Keov, Peter, López, Laura, Devine, Shane M., Valant, Celine, Lane, J. Robert, Scammells, Peter J., Sexton, Patrick M., Christopoulos, Arthur
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156061/
https://ncbi.nlm.nih.gov/pubmed/25006252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.582874
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