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Identification of Orthosteric and Allosteric Site Mutations in M(2) Muscarinic Acetylcholine Receptors That Contribute to Ligand-selective Signaling Bias
Muscarinic acetylcholine receptors contain at least one allosteric site that is topographically distinct from the acetylcholine, orthosteric binding site. Although studies have investigated the basis of allosteric modulation at these receptors, less is known about putative allosteric ligands that ac...
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| Glavni autori: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2010
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2844194/ https://ncbi.nlm.nih.gov/pubmed/20051519 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.094011 |
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