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Identification of Orthosteric and Allosteric Site Mutations in M(2) Muscarinic Acetylcholine Receptors That Contribute to Ligand-selective Signaling Bias

Muscarinic acetylcholine receptors contain at least one allosteric site that is topographically distinct from the acetylcholine, orthosteric binding site. Although studies have investigated the basis of allosteric modulation at these receptors, less is known about putative allosteric ligands that ac...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Gregory, Karen J., Hall, Nathan E., Tobin, Andrew B., Sexton, Patrick M., Christopoulos, Arthur
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Biochemistry and Molecular Biology 2010
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844194/
https://ncbi.nlm.nih.gov/pubmed/20051519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.094011
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