A Monod-Wyman-Changeux Mechanism Can Explain G Protein-coupled Receptor (GPCR) Allosteric Modulation

The Monod-Wyman-Changeux (MWC) model was initially proposed to describe the allosteric properties of regulatory enzymes and subsequently extended to receptors. Yet despite GPCRs representing the largest family of receptors and drug targets, no study has systematically evaluated the MWC mechanism as...

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Bibliografske podrobnosti
Main Authors: Canals, Meritxell, Lane, J. Robert, Wen, Adriel, Scammells, Peter J., Sexton, Patrick M., Christopoulos, Arthur
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Signal Transduction
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249119/
https://ncbi.nlm.nih.gov/pubmed/22086918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.314278
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