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Monod-Wyman-Changeux Analysis of Ligand-Gated Ion Channel Mutants
We present a framework for computing the gating properties of ligand-gated ion channel mutants using the Monod-Wyman-Changeux (MWC) model of allostery. We derive simple analytic formulas for key functional properties such as the leakiness, dynamic range, half-maximal effective concentration ([EC(50)...
Tallennettuna:
| Julkaisussa: | J Phys Chem B |
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| Päätekijät: | , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2017
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5551692/ https://ncbi.nlm.nih.gov/pubmed/28134524 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.6b12672 |
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