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Monod-Wyman-Changeux Analysis of Ligand-Gated Ion Channel Mutants

We present a framework for computing the gating properties of ligand-gated ion channel mutants using the Monod-Wyman-Changeux (MWC) model of allostery. We derive simple analytic formulas for key functional properties such as the leakiness, dynamic range, half-maximal effective concentration ([EC(50)...

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Detalhes bibliográficos
Publicado no:J Phys Chem B
Main Authors: Einav, Tal, Phillips, Rob
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5551692/
https://ncbi.nlm.nih.gov/pubmed/28134524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.6b12672
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