Regulation of G Protein-Coupled Receptors by Allosteric Ligands

by Lane, J. Robert, Abdul-Ridha, Alaa, Canals, Meritxell
Published 2013

Mechanistic Insights into Allosteric Structure-Function Relationships at the M(1) Muscarinic Acetylcholine Receptor

by Abdul-Ridha, Alaa, Lane, J. Robert, Mistry, Shailesh N., López, Laura, Sexton, Patrick M., Scammells, Peter J., Christopoulos, Arthur, Canals, Meritxell
Published in J Biol Chem (2014)

Molecular Determinants of Allosteric Modulation at the M(1) Muscarinic Acetylcholine Receptor

by Abdul-Ridha, Alaa, López, Laura, Keov, Peter, Thal, David M., Mistry, Shailesh N., Sexton, Patrick M., Lane, J. Robert, Canals, Meritxell, Christopoulos, Arthur
Published 2014

Diazepam is not a direct allosteric modulator of α(1)‐adrenoceptors, but modulates receptor signaling by inhibiting phosphodiesterase‐4

by Williams, Lisa M., He, Xiaoji, Vaid, Tasneem M., Abdul‐Ridha, Alaa, Whitehead, Alice R., Gooley, Paul R., Bathgate, Ross A.D., Williams, Spencer J., Scott, Daniel J.
Published in Pharmacol Res Perspect (2018)

Gram scale preparation of clozapine N-oxide (CNO), a synthetic small molecule actuator for muscarinic acetylcholine DREADDs

by van der Peet, Phillip L., Gunawan, Christian, Abdul-Ridha, Alaa, Ma, Sherie, Scott, Daniel J., Gundlach, Andrew L., Bathgate, Ross A.D., White, Jonathan M., Williams, Spencer J.
Published in MethodsX (2018)

Probing the correlation between ligand efficacy and conformational diversity at the α(1A)-adrenoreceptor reveals allosteric coupling of its microswitches

by Wu, Feng-Jie, Williams, Lisa M., Abdul-Ridha, Alaa, Gunatilaka, Avanka, Vaid, Tasneem M., Kocan, Martina, Whitehead, Alice R., Griffin, Michael D. W., Bathgate, Ross A. D., Scott, Daniel J., Gooley, Paul R.
Published in J Biol Chem (2020)