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Mechanistic Insights into Allosteric Structure-Function Relationships at the M(1) Muscarinic Acetylcholine Receptor
Benzylquinolone carboxylic acid (BQCA) is the first highly selective positive allosteric modulator (PAM) for the M(1) muscarinic acetylcholine receptor (mAChR), but it possesses low affinity for the allosteric site on the receptor. More recent drug discovery efforts identified 3-((1S,2S)-2-hydroxycy...
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| Publié dans: | J Biol Chem |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4246120/ https://ncbi.nlm.nih.gov/pubmed/25326383 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.604967 |
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