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Mechanistic Insights into Allosteric Structure-Function Relationships at the M(1) Muscarinic Acetylcholine Receptor
Benzylquinolone carboxylic acid (BQCA) is the first highly selective positive allosteric modulator (PAM) for the M(1) muscarinic acetylcholine receptor (mAChR), but it possesses low affinity for the allosteric site on the receptor. More recent drug discovery efforts identified 3-((1S,2S)-2-hydroxycy...
שמור ב:
| הוצא לאור ב: | J Biol Chem |
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| Main Authors: | , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
American Society for Biochemistry and Molecular Biology
2014
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4246120/ https://ncbi.nlm.nih.gov/pubmed/25326383 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.604967 |
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