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Molecular Mechanisms of Action and In Vivo Validation of an M(4) Muscarinic Acetylcholine Receptor Allosteric Modulator with Potential Antipsychotic Properties
We recently identified LY2033298 as a novel allosteric potentiator of acetylcholine (ACh) at the M(4) muscarinic acetylcholine receptor (mAChR). This study characterized the molecular mode of action of this modulator in both recombinant and native systems. Radioligand-binding studies revealed that L...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3055367/ https://ncbi.nlm.nih.gov/pubmed/19940843 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2009.194 |
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